Major in Bioinformatics, ZJU-UoE Institute, Zhejiang University 📧 ziwei.21@intl.zju.edu.cn
Find my CV here
I am a PhD student major in bioinformatics in Zhejiang University - University of Edinburgh (ZJU-UoE) institute. I am interested in multi-omics data analysis, focusing on developing machine-learning and deep-learning methods to gain deeper insights into the phenotypic diversity of immune cells in cancer and autoimmune diseases. My research centers on integrating the growing volume and diversity of next generation sequencing data across multiple modalities, including genomics, transcriptomics, proteomics, and immunomics, at bulk, single cell, and spatial resolutions, to provide a comprehensive view of immune system dynamics in disease contexts.
PhD Student major in Bioinformatics, ZJE institute, Zhejiang University
Bachelor major in Biomedical science, ZJE institute, Zhejiang University
Shenzhen Middle School
Xue, Z., Wu, L., Gao, B., Tian, R., Chen, Y., Qi, Y., Dong, T., Bai, Y., Zhao, Y., He, B., Wang, L., Liu, Z., Yao, J., Lu, L.#, Liu, W.# (2025). A pan-disease and population-level single-cell TCRαβ repertoire reference. Cell Discovery, 11, 82. link.
Tian, R., Xue, Z., Chen, Y., Qi, Y., Zhang, J., Yuan, J., Ruan, D., Lin, J., Liu, J., Wang, D., Ye, Y., & Liu, W.# (2025). Integrating cross-sample and cross-modal data for spatial transcriptomics and metabolomics with SpatialMETA. Nature Communications, 16, 8855. link.
Tian, R.*, Yu, Z.*, Xue, Z., Wu, J., Wu, L., Cai, S., Gao, B., He, B., Zhao, Y., Yao, J., Lu, L., Liu, W.# (2025). Evaluation of T Cell Receptor Construction Methods from scRNA-Seq Data. Genomics, Proteomics & Bioinformatics, qzae086. link.
Xue, Z.*, Wu, L.*, Tian, R., Gao, B., Zhao, Y., Bing, H., Zhao, B., Li, Y., Zhu, K., Wang, L., Yao, J.#, Liu, W.# & Lu, L.# Integrative mapping of human CD8+ T cells in inflammation and cancer. Nature Methods, 2025.
Guo, Y.*, Xue, Z., Gong, M., Jin, S., Wu, X. & Liu, W.# , (2025). CRISPR-TE: a web-based tool to generate single guide RNAs targeting transposable elements. Mobile DNA, .
Su, Y.* , Yu, Z. , Jin, S. , Ai, Z. Yuan, R. , Chen, X. , Xue, Z. , Guo, Y. , Chen, D., Liang, H., Liu, Z., Liu, W. (2025) Comprehensive assessment of mRNA isoform detection methods for long-read sequencing data. Nature Communications, 15, 3972 (link)
Tian, R.*, Xue, Z.*, Ruan, D., Chen, P., Xu, Y., Dai, C., Shen, W., Ouyang, H., Liu, W., and Lin, J. ( 2023). MSdb: An integrated expression atlas of human musculoskeletal system. iScience, 26, 106933. .
Li, Z., Xu, H., Li, J., Xu, X., Wang, J., Wu, D., Zhang, J., Liu, J., Xue, Z., Zhan, G., Tan, B.C.P., Chen, D., Chan, Y-S., Ng, H.H., Liu, W., Hsu, C-H., Zhang, D., Shen, Y. & Liang, H. (2023). Selective binding of retrotransposons by ZFP352 facilitates the timely dissolution of totipotency network. Nature Communications, 14, 3646. link.
Wu, L.* , Xue, Z.* , Jin, S., Zhang, J., Bai, Y., Jin, X., Wang, C., Wang, L., Wang, J.Q., Lu, L. & Liu, W.#. (2022) huARdb: human Antigen Receptor database for interactive clonotype-transcriptome analysis at the single-cell level. Nucleic Acid Research, 50(D1), D1244-D1254, .
Xiang, X.*, Tao, Y., DiRusso, J., Hsu, F.-M., Zhang, J., Xue, Z., Pontis, J., Trono, D., Liu, W., and Clark, A.T. (2022). Human reproduction is regulated by retrotransposons derived from ancient Hominidae-specific viral infections. Nature Communications, 13, 463. link.
Jin, S.* , Xue, Z.* , Zhang, J. , Wang, Z., Zhang, J., Chen, D.#, Liu, W.# , Lin, J.# (2021). Identification of SRSF3 target mRNAs using inducible TRIBE. Biochemical and Biophysical Research Communications. link.
Guo, Y.*, Xue, Z., Yuan, R., Li, J., Pastor, W. & Liu, W.# , (2021). RAD: a web application to identify region associated differentially expressed genes. Bioinformatics, btab075 ( link). The webtool is available in here.
Chu Kochen Scholarship of Zhejiang University (竺可桢奖学金)
National Scholarship of China (国家奖学金)
Qiu Shi Rising Star Ph.D. student Scholarship of Zhejiang University (求是新星培养计划)
Excellent Graduate Student of Zhejiang University (浙江大学优秀研究生)
Academic Poster Exhibition, College of Medicine, Zhejiang University (浙江大学医学院学术墙报展)
1st Interdisciplinary Innovation Competition, International Campus, Zhejiang University (浙江大学国际校区第一届交叉创新大赛)
A deep learning model for integration of scRNA-seq.
A deep learning model for antigen receptor clonotype-transcriptome analysis.
The human antigen receptor database.
The Region Associated DEG Web tool.
Efficiently store and access AnnData objects.