Major in Bioinformatics, ZJU-UoE Institute, Zhejiang University 📧 ziwei.21@intl.zju.edu.cn
Personal email: 📧 xueziweisz@gmail.com
I am a PhD student major in bioinformatics in Zhejiang University - University of Edinburgh joint institute. I am currently working in labW led by Dr. Wanlu Liu. I am currently working on genomic/multi-omics algorithm development, analysis, and front-end visualization.
I am currently is exploring the multi-omics data analysis in the field of bioinformatics and developing algorithms/tools for better understanding of transcriptome dynamics and clonal enrichment of antigen-receptors in cancers and autoimmune diseases. I am also developing methods for the integration of increasing amount and variety of next-generation sequnecing data for bioinformatics and biologist.
A deep learning model for integration of scRNA-seq.
A deep learning model for antigen receptor clonotype-transcriptome analysis.
The human antigen receptor database.
The Region Associated DEG Web tool.
Efficiently store and access AnnData objects.
PhD Student major in Bioinformatics, ZJE institute, Zhejiang University
Bachelor major in Biomedical science, ZJE institute, Zhejiang University
Shenzhen Middle School
Poster presenters in HCA Asia 2024
Tian, R.†, Yu, Z.†, Xue, Z., Wu, J., Wu, L., Cai, S., Gao, B., He, B., Zhao, Y., Yao, J., Lu, L., Liu, W. (2024). Evaluation of T Cell Receptor Construction Methods from scRNA-Seq Data. Genomics, Proteomics & Bioinformatics, qzae086. link.
Xue, Z.†, Wu, L.†, Tian, R., Gao, B., Zhao, Y., Bing, H., Zhao, B., Li, Y., Zhu, K., Wang, L., Yao, J.#, Liu, W.# & Lu, L.# Integrative mapping of human CD8+ T cells in inflammation and cancer. Nature Methods, 2024.
Guo, Y.†, Xue, Z., Gong, M., Jin, S., Wu, X. & Liu, W.# , (2024). CRISPR-TE: a web-based tool to generate single guide RNAs targeting transposable elements. Mobile DNA, .
Su, Y.† , Yu, Z. , Jin, S. , Ai, Z. Yuan, R. , Chen, X. , Xue, Z. , Guo, Y. , Chen, D., Liang, H., Liu, Z., Liu, W. (2024) Comprehensive assessment of mRNA isoform detection methods for long-read sequencing data. Nature Communications, 15, 3972 (link)
Tian, R.†, Xue, Z.†, Ruan, D., Chen, P., Xu, Y., Dai, C., Shen, W., Ouyang, H., Liu, W., and Lin, J. (2023). MSdb: An integrated expression atlas of human musculoskeletal system. iScience, 26, 106933. .
Li, Z., Xu, H., Li, J., Xu, X., Wang, J., Wu, D., Zhang, J., Liu, J., Xue, Z., Zhan, G., Tan, B.C.P., Chen, D., Chan, Y-S., Ng, H.H., Liu, W., Hsu, C-H., Zhang, D., Shen, Y. & Liang, H. (2023). Selective binding of retrotransposons by ZFP352 facilitates the timely dissolution of totipotency network. Nature Communications, 14, 3646. link.
Wu, L.† , Xue, Z.† , Jin, S., Zhang, J., Bai, Y., Jin, X., Wang, C., Wang, L., Wang, J.Q., Lu, L. & Liu, W.#. (2022) huARdb: human Antigen Receptor database for interactive clonotype-transcriptome analysis at the single-cell level. Nucleic Acid Research, 50(D1), D1244-D1254, .
Xiang, X.†, Tao, Y., DiRusso, J., Hsu, F.-M., Zhang, J., Xue, Z., Pontis, J., Trono, D., Liu, W., and Clark, A.T. (2022). Human reproduction is regulated by retrotransposons derived from ancient Hominidae-specific viral infections. Nature Communications, 13, 463. link.
Jin, S.† , Xue, Z.† , Zhang, J. , Wang, Z., Zhang, J., Chen, D.#, Liu, W.# , Lin, J.# (2021). Identification of SRSF3 target mRNAs using inducible TRIBE. Biochemical and Biophysical Research Communications. link.
Guo, Y.†, Xue, Z., Yuan, R., Li, J., Pastor, W. & Liu, W.# , (2021). RAD: a web application to identify region associated differentially expressed genes. Bioinformatics, btab075 (link). The webtool is available in here.